1. Implement, coordinate and facilitate the National Response.
2. Manage and coordinate the implementation of HIV and AIDS related Government policies.
3. Provide technical support to Government in the formulation and review of HIV and AIDS policies.
4. Develop and maintain an up-to-date information system and establish suitable mechanisms of dissemination and utilization of information.
5. In liaison with the Secretary responsible for HIV and AIDS, monitor and evaluate progress and impact of the National Response.
6. Mobilize and equitably disburse resources towards the National Response.
7. Monitor distribution and effective and efficient utilization of resources towards the National Response.
8. Promote and commission research, information sharing and documentation.
9. Liaise with all Government Departments, Ministries and Agencies on matters relating to the National Response and to ensure that there are no barriers to information.
10. Advocate for a strong, sustained and visible role of political, civil and traditional leaders.
11. Accredit information relating to HIV and AIDS produced by anyone before dissemination.
Develop and maintain profiles.
12. Provide technical guidance, capacity building and support to stakeholders.
13. Submit reports to the Minister on the implementation of the National Response.