The response to HIV and AIDS requires a multi-sectoral approach as it encompasses broad issues of population, economic development and management, social service provision, culture, community development, human rights as well as gender. Therefore, NAC works in partnership with all sectors which include the public sector, private sector, faith-based organisations, non-governmental organisations, civil society organisations, networks and organisations of People Living with HIV as well as research and academic institutions in order to achieve the overall goal of the response to HIV and AIDS.

Activities of all players in the National Response to HIV and AIDS are guided by the HIV and AIDS Prevention and Management Act and the National HIV and AIDS Policy which is operationalized through the National HIV and AIDS Strategic Plan. These frameworks are aligned to the Government of Malawi's overarching socio-economic development framework, the Malawi Growth and Development Strategy.